1 2 3 Dry eye modifies the thermal and menthol responses in rat corneal primary afferent 4 cool cells
نویسندگان
چکیده
Abbreviated title: Dry eye-induced sensitization of cool cells 15 Number of pages: 29 16 Number of figures: 6 17 Number of words: Abstract, 248; Introduction, 499; Discussion, 1368 18 19 Acknowledgements: Funding for these studies was provided by the National Eye 20 Institute R01EY021230 to I.D.M and the National Institute of General Medical Sciences 21 P20GM103643. The authors declare no competing financial interests. 22 23
منابع مشابه
Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells.
Dry eye syndrome is a painful condition caused by inadequate or altered tear film on the ocular surface. Primary afferent cool cells innervating the cornea regulate the ocular fluid status by increasing reflex tearing in response to evaporative cooling and hyperosmicity. It has been proposed that activation of corneal cool cells via a transient receptor potential melastatin 8 (TRPM8) channel ag...
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Corneal primary afferent neurons that respond to drying of the ocular surface have been previously characterized and found to respond to innocuous cooling, menthol, and hyperosmotic stimuli. The purpose of the present study was to examine the receptive field properties of second-order neurons in the trigeminal nucleus that respond to drying of the ocular surface. Single-unit electrophysiologica...
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This study reports the findings of two classes of corneal afferents excited by drying of the cornea (dry responses) in isoflurane-anesthetized rats: cold-sensitive (CS; 87%) and cold-insensitive (CI; 13%) neurons. Compared with CI neurons, CS neurons showed significantly higher firing rates over warmer corneal temperatures (~31-15°C) and greater responses to menthol, drying, and wetting of the ...
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